The Israeli military also advanced further north into Lebanon as Hezbollah forces mull a U.S. brokered cease-fire agreement that would bring an end to 13 months of exchanges of fire between the two sides.
The Israeli military blames civilian deaths on Hamas, accusing militants of hiding among civilians and fighting from residential areas.
Since late September, Israel has dramatically escalated its bombardment of Lebanon, vowing to cripple the militant group Hezbollah and end its barrages into Israel.
A third child, 10 years old, was wounded in the strike overnight in the southern city of Khan Younis, according to the Civil Defense, first responders who operate under the Hamas-run government.