The move comes as the Trump administration in his first two weeks in office has prioritized executing his plans for the mass deportation of illegal immigrants from the U.S., plans that he oft-touted on the campaign trail last year.
Asked repeatedly on NBC News whether women, children and families would be among those held at the detention center, Homeland Security Secretary Kristi Noem declined to directly answer.
Marines arrived at the Guantanamo Bay Naval Base in Cuba on Sunday.
The planned flights this weekend would be the first time migrants are sent to Guantanamo Bay, a move that presents unique legal and logistical challenges.